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pentobarbital will lessen the extent or effect of dienogest/estradiol valerate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Women must not opt for estradiol valerate/dienogest as their contraceptive when making use of potent CYP3A4 inducers on account of prospective lessen in contraceptive efficacy.pentobarbital will